Fig. 3. Mapping mechano-sensitivity of ion channels at cilia base (A), cilia tip (B) and extra-ciliary regions (C). The left panels illustrate the displacement, the middle panels show the effect of the displacement on the mean normalised open probability P_o of channels at pipette potential of -140 mV, and the right panels show example single-channel recordings. All values are shown as mean ± S.E.M (n=5 at cilia base, n = 3 at cilia tip, n = 5 at extra-ciliary regions. Significant differences with respect to zero displacement under control conditions (absence of Gd³⁺) are marked as *p<0.05 and ** p<0.01 (open symbols). Significant differences with respect to zero displacement in presence of Gd³⁺ are shown as ⁺p<0.05 and ⁺⁺p<0.01 (closed symbols).